This distinguished lecture honors Britton Chance

Britton Chance (1913-2010) was a world leader in transforming theoretical science into useful biomedical and clinical applications. Among his pioneering contributions to fundamental biomedical science were his discovery of numerous enzyme-substrate compounds, World War II development of computers for Radar, the elucidation of the fundamental principles of control of bioenergetics and metabolism, the first human subject study using 31P NMR (phosphorous nuclear magnetic resonance) spectroscopy and more recently optical spectroscopy and imaging of human brain and breast. Through decades of scholarly mentorship of colleagues in disciplines ranging from mathematics to clinical medicine, he brought additional distinction to this University and multiplied its contributions to improving the human condition.

Professor Chance was Eldridge Reeves Johnson University Professor of Biophysics, Physical Chemistry and Radiologic Physics at Penn. He received his undergraduate degree from Penn’s Towne Scientific School in 1935 and doctoral degrees from both Penn and the University of Cambridge. He was a member of the National Academy of Sciences and of the Institute of Medicine and a Foreign Member of the Royal Society of London. Among very many other recognitions, he received the National Medal of Science, the Benjamin Franklin Medal from the American Philosophical Society, the Biological Physics Prize from the American Physical Society, and honorary degrees from the Karolinska Institut, the Medical College of Ohio at Toledo, Semmelweis University, Hahnemann Medical College and the Universities of Pennsylvania, Helsinki, Dusseldorf and Buenos Aires. In his honor, Huazhong University of Science and Technology named a major laboratory as the Britton Chance Center for Biomedical Photonics

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Britton Chance Distinguished Lecture in Engineering and Medicine

Samir MitragotriLinda G. Griffith
S.E.T.I. Professor of Biological and Mechanical Engineering
Massachusetts Institute of Technology

PhysioMimetics: How Integration of Systems Biology with Organs-on-Chips May Humanize Therapeutic Development

Wednesday, October 25, 2017, 3:00 PM, Wu and Chen Auditorium, Levine Hall

“Mice are not little people” is a refrain that is becoming louder as the strengths and weaknesses of animal models of human disease become more apparent. At the same time, three emerging approaches are headed toward integration: systems biology analysis of cell-to-cell and intracellular signaling networks in patient-derived samples; 3D tissue-engineered models of human organ systems, often made from stem cells; and micro and mesofluidic devices that enable 3D “microphysiological systems (MPSs)” to be sustained, interconnected, perturbed and analyzed for weeks in culture. This talk will describe the recent work of Dr. Griffith and her group in integrating these approaches to study chronic inflammatory diseases, with an emphasis on building and characterizing 3D mucosal barrier models of endometrium and gut, and the deployment of these models to analyze inflammation and multi-MPS cross talk.

Speaker Biography:

Linda G. Griffith, Ph.D. (UC Berkeley, Chemical Engineering), is the School of Engineering Teaching Innovation Professor of Biological and Mechanical Engineering and MacVicar Teaching Fellow at MIT, where she directs the Center for Gynepathology Research and the Human Physiome on a Chip Project. She led development of MIT’s undergraduate major in Biological Engineering, which launched in 2005 as MIT’s first new major in almost 40 years. Several technologies from her lab have been commercialized, including the 3D Printing process for tissue engineering, and the Liverchip.

She is a member of the National Academy of Engineering and her awards include a MacArthur Foundation Fellowship and the Popular Science Brilliant 10 Award. She has served as a member of two NIH Advisory Councils (NIDCR and NIAMS) and currently serves on the Advisory Committee to the Director of the NIH.

Previous Britton Chance Distinguished Lecturers

1995 Lewis S. Edelheit, General Electric Company
1996   Douglas A. Lauffenburger, Massachusetts Institute of Technology

George Georgiou, University of Texas at Austin
1999 Jeffrey A. Hubbell, University of Zürich
2000 W. Mark Saltzman, Cornell University
2001 Chaitan S. Khosla, Stanford University
2002 Sangtae Kim, Lilly Research Laboratories
2003 Larry V. McIntire, Rice University
2004     Deborah E. Leckband, University of Illinois at Urbana-Champaign
2004 Stephen R. Quake, Stanford University
2005 Frances H. Arnold, California Institute of Technology
2006 Adam P. Arkin, University of California at Berkeley
2007 Kristi S. Anseth, University of Colorado at Boulder
2008 Jay D. Keasling, University of California at Berkeley

Mark E. Davis, California Institute of Technology


David A. Tirrell, California Institute of Technology


Frank S. Bates, University of Minnesota


Arup K. Chakraborty, Massachusetts Institute of Technology

2013 Melody A. Swartz, Ecole polytechnique federale de Lausanne

James C. Liao, University of California, Los Angeles
Samir Mitragotri, University of California, Santa Barbara
David Mooney, Harvard School of Engineering and Applied Science