This distinguished lecture honors Britton Chance

Britton Chance (1913-2010) was a world leader in transforming theoretical science into useful biomedical and clinical applications. Among his pioneering contributions to fundamental biomedical science were his discovery of numerous enzyme-substrate compounds, World War II development of computers for Radar, the elucidation of the fundamental principles of control of bioenergetics and metabolism, the first human subject study using 31P NMR (phosphorous nuclear magnetic resonance) spectroscopy and more recently optical spectroscopy and imaging of human brain and breast. Through decades of scholarly mentorship of colleagues in disciplines ranging from mathematics to clinical medicine, he brought additional distinction to this University and multiplied its contributions to improving the human condition.

Professor Chance was Eldridge Reeves Johnson University Professor of Biophysics, Physical Chemistry and Radiologic Physics at Penn. He received his undergraduate degree from Penn’s Towne Scientific School in 1935 and doctoral degrees from both Penn and the University of Cambridge. He was a member of the National Academy of Sciences and of the Institute of Medicine and a Foreign Member of the Royal Society of London. Among very many other recognitions, he received the National Medal of Science, the Benjamin Franklin Medal from the American Philosophical Society, the Biological Physics Prize from the American Physical Society, and honorary degrees from the Karolinska Institut, the Medical College of Ohio at Toledo, Semmelweis University, Hahnemann Medical College and the Universities of Pennsylvania, Helsinki, Dusseldorf and Buenos Aires. In his honor, Huazhong University of Science and Technology named a major laboratory as the Britton Chance Center for Biomedical Photonics

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Britton Chance Distinguished Lecture in Engineering and Medicine

The 2015 Britton Chance Distinguished Lecture in Engineering and Medicine sponsored by the Department of Chemical and Biomolecular Engineering.

Samir MitragotriDr. Samir Mitragotri

Professor of Chemical Engineering
University of California, Santa Barbara (UCSB)

"Innovative Systems for Effective Delivery of Therapeutics"

Wednesday, October 14, 2015, 3:00 PM, Wu and Chen Auditorium, Levine Hall

Effective delivery of therapeutics is a major problem in today’s healthcare. For example, in the case of protein and peptide drugs such as insulin, growth hormones, and vaccines, a key challenge is their stabilization and delivery without having to use needles. All proteins are currently delivered by needles, which have several limitations including pain, needle-phobia, and contamination caused by dirty needles. Our laboratory is addressing this challenge by delivering proteins using transdermal patches and oral pills. Neither of these routes is inherently suited for protein delivery since they offer significant diffusive and enzymatic barriers for protein transport. We have developed a number of technologies that overcome these barriers to deliver proteins for the treatment of diabetes, osteoporosis, psoriasis and several other diseases. I will present an overview of these technologies with respect to their principles and applications. Targeting of drugs to specific tissues is also a key challenge in therapeutic delivery. This is especially problematic for cancer and cardiovascular diseases, where the effectiveness of drugs is limited by their poor accumulation at the disease tissue and high accumulation in healthy tissues. Our laboratory is developing nanoparticles that can encapsulate chemotherapeutic drugs and target them to tumors. Our strategy explores biomimetic designs that leverage the principles of natural cells such as platelets and red blood cells to accomplish excellent targeting. I will present an overview of some the targeting strategies for the treatment of breast cancer and vascular bleeding after trauma.

Speaker Biography:

Dr. Samir Mitragotri is a Professor of Chemcial Engineering at the Univesity of California, Santa Barbara (UCSB). He is also the founding Director of the Center for Bioengineering at UCSB, Professor Mitragotri received Ph.D. from MIT in 1996 and B.S. from the Institute of Chemical Technology, Mumbai in 1992, both in Chemical Engineering.

Professor Mitragotri has pioneered new technologies to deliver medicines without using needles. Effective delivery of medicines to patients for the treatment of life-threatening diseases is a major problem, especially for biopharmaceutical drugs (large molecules) that are increasingly dominating the repertoire of pharmaceutical products. Currently, these drugs have to be delivered by injections. Professor Mitragotri has addressed this challenge by developing innovative technologies for needle-free drug delivery via skin patches and oral pills which are easy-to-use, patient-friendly, and safe. In addition, he has made groundbreaking contributions to the field of targeted drug delivery for the treatment of cancer and vascular diseases.

Professor Mitragotri has published close to 200 papers in leading journals including Science, Nature Biotechnology, Nature Materials, ACS Nano and PNAS. His work has been highlighted in numerous popular and news media including Scientific American, Popular Science, R&D Magazine, New York Times, USA Today and Discover Magazine. His publications have been cited more than 16,000 times (h-index of 72).

Professor Mitragotri has received numerous awards for his work including his election to the National Academy of Engineering (NAE) in 2015. He is also an elected fellow of the National Academy of Inventors (NAI), the American Association of Advancement of Science (AAAS), Controlled Release Society (CRS) and the American Institute of Medical and Biological Engineers (AIMBE). He was among the first to be recognized with the Technology Review Young Inventor award (TR35) for technological innovation and is also a recipient of the Distinguished Alumnus award from Institute of Chemical Technology. Prof. Mitragotri is a recipient of Colburn award and Andreas Acrivos Professional progress award from AIChE.

Professor Mitragotri is an outstanding innovator and entrepreneur. He has put an extraordinary emphasis on converting his discoveries into clinically usable technologies for the benefit of patients. He is an inventor on over 100 issued and pending patents that have been licensed by ten companies. He has co-founded seven companies which have developed (and are developing) over 30 products in therapeutics, diagnostics, and personal care. Products developed by his companies have received Edison awards for Innovation on three occasions.

Previous Britton Chance Distinguished Lecturers

1995 Lewis S. Edelheit, General Electric Company
1996   Douglas A. Lauffenburger, Massachusetts Institute of Technology

George Georgiou, University of Texas at Austin
1999 Jeffrey A. Hubbell, University of Zürich
2000 W. Mark Saltzman, Cornell University
2001 Chaitan S. Khosla, Stanford University
2002 Sangtae Kim, Lilly Research Laboratories
2003 Larry V. McIntire, Rice University
2004     Deborah E. Leckband, University of Illinois at Urbana-Champaign
2004 Stephen R. Quake, Stanford University
2005 Frances H. Arnold, California Institute of Technology
2006 Adam P. Arkin, University of California at Berkeley
2007 Kristi S. Anseth, University of Colorado at Boulder
2008 Jay D. Keasling, University of California at Berkeley

Mark E. Davis, California Institute of Technology


David A. Tirrell, California Institute of Technology


Frank S. Bates, University of Minnesota


Arup K. Chakraborty, Massachusetts Institute of Technology

2013 Melody A. Swartz, École polytechnique fédérale de Lausanne
2014 James C. Liao, University of California, Los Angeles